Repost: Stinker or Smeller?

First published 04/2009 over at EP v2.0. The topic came up in conversation in the last couple of weeks so I thought I’d dig the post out! The images have disappeared but it makes sense without.

One of the advantages of resolving to ‘buy British’ (or vaguely European) is rediscovering the latest trend in culinary adventure: seasonality! With the advent of the asparagus season comes that intriguing question – why does asparagus make some people’s pee smell?

It turns out that the answer isn’t as simple as I first anticipated. I thought it would be a simple exercise in looking up the chemical responsible, reading a little around metabolic pathways and degradation products and suggesting which volatile and vile molecule is responsible. Not everyone can smell asparagus pee however, and this initially lead to the assumption that not everyone breaks down asparagus in a manner that produces the smell. Adopting the naming convention of one paper[1], those who produce asparagus pee are stinkers, and those who can smell it are smellers.

There have been a number of studies that investigate the origin of asparagus pee and range from feeding unsuspecting students various compounds that might be responsible for the smell, to making people eat asparagus every month to see if it keeps on happening. It is widely noted that the first reports of asparagus pee correlate well with the first use of sulfur containing fertilizers from the late 17th century[1]. This give a fairly decent clue (as if the smell didn’t) that sulfur compounds are to blame.
It isn’t that simple though, and the issue of stinkers versus smellers still exists. Some studies suggest that about half of the UK population are capable of producing the odour, but closer to three quarters of the American population are[2]. The sample size was small, and those results are from two different studies, also other studies contradict these findings so I’ll take those results with a pinch of salt. Another paper suggests that everyone is a stinker but not everyone is a smeller leading to the illusion that not everyone is a stinker, and also that some people may be hypersensitive, specifically sensitive to the pungent compounds[3]. Confused yet?
As far as I can tell (and as far as my journal access will let me go), the jury is still out on the precise nature of the variation between stinkers and smellers. There was one rather intriguing anecdote about women who, on becoming pregnant, started to notice asparagus pee. This could well mean that the women were smellers, but not stinkers, while the unborn children were stinkers[1]. Also, not everyone describes the smell in the same way: to some it is hideous enough to stop them eating asparagus, to others it is not unpleasant, just a bit strange.
I’ve still not answered my question though, what are the chemicals involved? Asparagusic acid  is looking like a likely culprit as subjects fed that substance produced pee smelling suspiciously asparagus like. The current thinking is that asparagusic acid is broken down into a variety of sulfur containing compounds that then go on to break down into a collection of volatile and pungent sulfur compounds in urine. These intermediates are not known, and characterising them is probably difficult due to the hazards of trying to extract them from urine without altering them chemically. The final compounds must be volatile for the odour to be detected. These include methanethiol, dimethyl sulfide and bis(methothio)methane, which is reported to be reminiscent of cheese, horseraddish, onions, garlic, truffles, with earthy and spicy notes (on the right above).
I suppose that the precise nature of asparagus pee is not a burning research question because that was about all the information I could find. Still, I think I’m mostly satisfied with a tenuous explanation involving stinkers and smellers, aparagusic acid and breakdown products. After all, asparagus is still good eating!
[1] Akers et al., Food & Foodways, 1997 (2) 131
[2] Mitchell, Drug Metabolism and Disposition, 2001, (29), 539
[3] Lison et al., British Medical Journal, 1980 (281) 1676

5 thoughts on “Repost: Stinker or Smeller?

  1. This is exactly the kind of research that I find funny and strange. It is just a bit on the edge of strange… . but interesting. I mean, why would some smell and some stink? (I know, you said something about it in the end about babies and mothers… ) anyhow, interesting and I will go to the links and read a bit more. THanks!

  2. I became a stinker when I moved from the UK to Canada; before that I had no idea what people were talking about when they mentioned “asparagus pee”! So the mention of fertiliser and higher rates of stinkiness in North America has some cogs turning…
    I feel sorry for people who hate the smell so much they can’t eat asparagus at all. It’s a staple of my diet!

  3. Like Asa, I find it quite fascinating, and pretty irrelevant on some levels. I was hoping for a few more recent studies that were more difinitive but I guess we’ve moved on to other problems.
    I think I’ve fixed the images now.

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